| 2021/12/09 | Talleres |  | 0-0 (4-5 pens) |  | Boca Juniors |
| 2021/11/04 | Boca Juniors | | 1-0 |  | Argentinos Juniors | ||||
| 2021/12/02 | Talleres | | 1-0 |  | Godoy Cruz |
| 2021/09/23 | Boca Juniors | | 0-0 (4-2 pens) |  | Patronato | ||||
| 2021/09/30 | Temperley |  | 1-2 | | Talleres | ||||
| 2021/10/07 | Godoy Cruz | | 1-0 |  | Tigre | ||||
| 2021/10/14 | Argentinos Juniors | | 2-1 |  | San Telmo |
| 2021/07/13 | Villa San Carlos |  | 0-1 | | Patronato | ||||
| 2021/07/14 | San Telmo | | 1-0 |  | Banfield | ||||
| 2021/07/20 | Sarmiento de Junín |  | 0-1 | | Temperley | ||||
| 2021/08/04 | Boca Juniors | | 0-0 (4-1 pens) |  | River Plate | ||||
| 2021/08/12 | Estudiantes Río Cuarto |  | 1-1 (5-6 pens) | | Talleres | ||||
| 2021/08/18 | Gimnasia |  | 2-3 | | Argentinos Juniors | ||||
| 2021/09/09 | Defensa y Justicia |  | 0-0 (4-5 pens) | | Tigre | ||||
| 2021/09/22 | Godoy Cruz | | 3-3 (5-4 pens) |  | Racing Club |
| 2021/03/17 | Deportivo Laferrere |  | 0-2 | | San Telmo | ||||
| Colón |  | 0-1 | | Argentinos Juniors | |||||
| 2021/03/24 | Gimnasia | | 5-0 |  | Dock Sud | ||||
| Boca Juniors | | 3-0 |  | Defensores de Belgrano V.R | |||||
| 2021/03/25 | San Lorenzo |  | 0-2 | | Defensa y Justicia | ||||
| 2021/04/07 | Patronato | | 2-2 (5-3 pens) |  | Lanús | ||||
| Talleres | | 1-1 (3-1 pens) |  | Vélez Sarsfield | |||||
| 2021/04/08 | Atlético Tucumán |  | 1-2 | | River Plate | ||||
| 2021/04/15 | San Martin San Juan |  | 2-2 (1-4 pens) | | Racing Club | ||||
| 2021/04/21 | Huracán Las Heras |  | 1-4 | | Estudiantes Río Cuarto | ||||
| 2021/04/28 | Deportivo Madryn |  | 0-1 | | Banfield | ||||
| 2021/05/17 | Newell´s Old Boys |  | 0-1 | | Sarmiento de Junín | ||||
| 2021/05/19 | Talleres-RdE |  | 0-4 | | Temperley | ||||
| 2021/08/04 | Tigre | | 2-1 |  | Independiente |
| 1st Leg | 2nd Leg | |||||||
|---|---|---|---|---|---|---|---|---|
 | (3-3) |  | 2-1 | 1-2 (0 pens-3) | ||||
 | (1-7) | | 0-2 | 1-5 | ||||
 | (4-4) |  | 2-3 | 2-1 | ||||
 | (3-3) |  | 2-2 | 1-1 | ||||
 | (2-3) |  | 2-2 | 0-1 | ||||
| (4-1) |  | 1-0 | 3-1 | ||||
 | (3-2) |  | 1-1 | 2-1 | ||||
 | (1-3) |  | 1-2 | 0-1 | ||||
 | (2-0) |  | 1-0 | 1-0 | ||||
| (0-1) |  | 0-0 | 0-1 | ||||
 | (1-2) |  | 1-1 | 0-1 | ||||
 | (1-1) |  | 0-0 | 1-1 | ||||
 | (1-5) |  | 0-1 | 1-4 |
