| 2021/12/04 | Portland Timbers | 2-0 | Real Salt Lake |
| 2021/12/05 | Philadelphia Union | 1-2 | New York City FC |
| 2021/11/25 | Colorado Rapids | 0-1 | Portland Timbers | ||||
| 2021/11/28 | Sporting KC | 1-2 | Real Salt Lake |
| M | G | A | Pts | ||
|---|---|---|---|---|---|
| 1 | NE Revolution | 34 | 65 | 41 | 73 |
| 2 | Philadelphia Union | 34 | 48 | 35 | 54 |
| 3 | Nashville SC | 34 | 55 | 33 | 54 |
| 4 | New York City FC | 34 | 56 | 36 | 51 |
| 5 | Atlanta United | 34 | 45 | 37 | 51 |
| 6 | Orlando City | 34 | 50 | 48 | 51 |
| 7 | NY Red Bulls | 34 | 39 | 33 | 48 |
| 8 | DC United | 34 | 56 | 54 | 47 |
| 9 | Columbus Crew | 34 | 46 | 45 | 47 |
| 10 | CF Montréal | 34 | 46 | 44 | 46 |
| 11 | Inter Miami CF | 34 | 36 | 53 | 41 |
| 12 | Chicago Fire | 34 | 36 | 54 | 34 |
| 13 | Toronto FC | 34 | 39 | 66 | 28 |
| 14 | FC Cincinnati | 34 | 37 | 74 | 20 |
| M | G | A | Pts | ||
|---|---|---|---|---|---|
| 1 | Colorado Rapids | 34 | 51 | 35 | 61 |
| 2 | Seattle Sounders | 34 | 53 | 33 | 60 |
| 3 | Sporting KC | 34 | 58 | 40 | 58 |
| 4 | Portland Timbers | 34 | 56 | 52 | 55 |
| 5 | Minnesota United | 34 | 42 | 44 | 49 |
| 6 | Vancouver Whitecaps | 34 | 45 | 45 | 49 |
| 7 | Real Salt Lake | 34 | 55 | 54 | 48 |
| 8 | LA Galaxy | 34 | 50 | 54 | 48 |
| 9 | Los Angeles FC | 34 | 53 | 51 | 45 |
| 10 | SJ Earthquakes | 34 | 46 | 54 | 41 |
| 11 | FC Dallas | 34 | 47 | 56 | 33 |
| 12 | Austin FC | 34 | 35 | 56 | 31 |
| 13 | Houston Dynamo | 34 | 36 | 54 | 30 |
 | |
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WINNER | |||||||||
TOP GOAL SCORER | |||||||||
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MOST ASSISTS | |||||||||
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EDITION STATISTICS | |||||||||
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| Statistics complete! |
