| Pts | G | W | D | L | GS | GC | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Eintracht Frankfurt | 12 | 6 | 3 | 3 | 0 | 10 | 6 |
| 2 |  | Olympiacos | 9 | 6 | 3 | 0 | 3 | 8 | 7 |
| 3 |  | Fenerbahçe | 6 | 6 | 1 | 3 | 2 | 7 | 8 |
| 4 |  | Royal Antwerp | 5 | 6 | 1 | 2 | 3 | 6 | 10 |
| 2021/09/16 | Grp.D | Eintracht Frankfurt | | 1-1 | | Fenerbahçe | ||||
| 2021/09/16 | Grp.D | Olympiacos | | 2-1 | | Royal Antwerp | ||||
| 2021/09/30 | Grp.D | Royal Antwerp | | 0-1 | | Eintracht Frankfurt | ||||
| 2021/09/30 | Grp.D | Fenerbahçe | | 0-3 | | Olympiacos | ||||
| 2021/10/21 | Grp.D | Fenerbahçe | | 2-2 | | Royal Antwerp | ||||
| 2021/10/21 | Grp.D | Eintracht Frankfurt | | 3-1 | | Olympiacos | ||||
| 2021/11/04 | Grp.D | Olympiacos | | 1-2 | | Eintracht Frankfurt | ||||
| 2021/11/04 | Grp.D | Royal Antwerp | | 0-3 | | Fenerbahçe | ||||
| 2021/11/25 | Grp.D | Olympiacos | | 1-0 | | Fenerbahçe | ||||
| 2021/11/25 | Grp.D | Eintracht Frankfurt | | 2-2 | | Royal Antwerp | ||||
| 2021/12/09 | Grp.D | Fenerbahçe | | 1-1 | | Eintracht Frankfurt | ||||
| 2021/12/09 | Grp.D | Royal Antwerp | | 1-0 | | Olympiacos |
 | Qualification |
| Play-off Qualification |
|
| 2 |
|
Karl Toko-Ekambi Lyon | 6 G |
| 2 |
|
Wenderson Galeno FC Porto | 6 G |
| 4 |
|
Daichi Kamada Eintracht Frankfurt | 5 G |
| 4 |
|
Patson Daka Leicester City | 5 G |
| 1 |
|
Filip Kostic Eintracht Frankfurt | 4 AST |
| 1 |
|
Ricardo Horta SC Braga | 4 AST |
| 1 |
|
Iuri Medeiros SC Braga | 4 AST |
| 5 |
|
Victor Moses Spartak Moskva | 3 AST |
![Europa League [Qual.]](/img/bandeiras/3276_comp_el_20150921134310.jpg "Europa League [Qual.]"){kind=small}
