| 14-05 | 23:00 | Racing |  | vs |  | Nacional | Grp.F |  | |||
| 15-05 | 01:00 | Defensa y Justicia |  | vs |  | Independiente Medellín | Grp.A | 1.89 | 3.45 | 4.08 | h2h |
| 15-05 | 01:00 | Sportivo Ameliano |  | vs |  | Rayo Zuliano FC | Grp.E | h2h | |||
| 15-05 | 01:30 | Corinthians |  | vs |  | Argentinos Juniors | Grp.F | 1.81 | 3.34 | 4.71 | h2h |
| 15-05 | 03:00 | Nacional Potosí |  | vs |  | Sportivo Trinidense | Grp.D | 1.22 | 6.30 | 11.60 | h2h |
| 14-05 | 23:00 | LDU Quito |  | vs |  | Junior Barranquilla | Grp.D | 1.50 | 4.33 | 6.50 |  |
| 14-05 | 23:00 | Peñarol |  | vs |  | Atlético Mineiro | Grp.G | 3.09 | 3.26 | 2.37 | |
| 14-05 | 23:00 | Talleres |  | vs |  | Cobresal | Grp.B | 1.19 | 7.00 | 14.50 | |
| 15-05 | 01:30 | River Plate |  | vs |  | Libertad | Grp.H | 1.37 | 5.00 | 8.20 | |
| 15-05 | 03:00 | Millonarios |  | vs |  | Palestino | Grp.E | 1.55 | 4.05 | 7.50 | |
| 14-05 | 18:30 | Osasuna |  | vs |  | Mallorca | D36 | 2.87 | 3.00 | 3.00 | |
| 14-05 | 20:30 | Real Madrid |  | vs |  | Alavés | D36 | 1.23 | 7.35 | 14.90 | |
| 14-05 | 21:00 | Girona |  | vs |  | Villarreal | D36 | 1.73 | 4.72 | 4.41 | |
| 14-05 | 20:00 | Tottenham |  | vs |  | Manchester City | D34 | 7.50 | 6.02 | 1.40 | |
| 15-05 | 00:00 | North Carolina FC |  | vs |  | Loudoun United | Grp.East | 1.75 | 3.63 | 4.29 |  |
| 13-05 | 23:00 | Gimnasia |  | 3-1 |  | Vélez Sarsfield | 1S | ||||
| 14-05 | 01:00 | Unión |  | 1-0 |  | Banfield | 1S |
