| 20-05 | 23:00 | Charleston Battery |  | vs |  | Atlanta United | L16 | h2h | |||
| 20-05 | 23:00 | Los Angeles FC |  | vs |  | Loudoun United | L16 | h2h | |||
| 20-05 | 23:00 | Seattle Sounders |  | vs |  | Phoenix Rising | L16 | h2h | |||
| 20-05 | 23:00 | Sacramento Republic |  | vs |  | SJ Earthquakes | L16 | h2h | |||
| 20-05 | 23:00 | Tampa Bay Rowdies |  | vs |  | FC Dallas | L16 | h2h | |||
| 20-05 | 23:00 | Sporting KC |  | vs |  | FC Tulsa | L16 | h2h | |||
| 22-05 | 00:30 | New York City FC B |  | vs |  | New Mexico United | L16 | h2h |
| 20-05 | 17:30 | Salernitana |  | 1-2 |  | Hellas Verona | D37 | ||||
| 20-05 | 19:45 | Bologna |  | 3-3 |  | Juventus | D37 |
| 22-05 | 01:10 | Temperley |  | vs |  | River Plate | L32 | 11.30 | 5.52 | 1.21 | h2h |
| 20-05 | 23:00 | San Lorenzo |  | 1-1 |  | Lanús | 1S | ||||
| 21-05 | 01:15 | Racing Club |  | 3-0 |  | Argentinos Juniors | 1S | ||||
| 21-05 | 01:15 | Rosario Central |  | 1-1 |  | Tigre | 1S | ||||
| 22-05 | 00:00 | Vélez Sarsfield |  | vs |  | Newell´s Old Boys | 1S | 2.12 | 3.12 | 3.85 |  |
| 20-05 | 20:00 | HFX Wanderers |  | 1-2 |  | Valour FC | L |
